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that utilised quantitative polymerase chain reaction (qPCR) given that the diagnostic Software for pathogen detection to estimate the ORs of diarrhoea presented pathogen detection. GEMS is often a seven web page, case-Management study of reasonable-to-intense diarrhoea in small children younger than five a long time in south Asia and sub-Saharan Africa.
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Validation reports have proven that the use of molecular diagnostics is much more delicate than is standard laboratory diagnostic approaches to the detection of diarrhoeal pathogens.
Simply because many of the scientific studies published on this matter applied a case definition according to non-molecular diagnostics, we utilized the sensitivity and specificity of those methods when compared with our qPCR case definition (appendix p 15) wikipedia reference to accurate the proportion estimates for publicity misclassification resulting from diagnostic error.